HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 117942247, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 178472327 | HCID 178472327 | — |
| Product | HCID 117942247 | HCID 117942247 | — |
Reaction Steps
Hydrolysis of (S)-ethyl 8-(2-amino-6-((R)-1-(3,4-dihydroquinazolin-6-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate (a by-product from the N-CBZ deprotection of Example 55bk) using the LiOH general method provided the title compound as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199994B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-40d29efeff0e4b4bab76b3365fdfa9f0 |
| Source note | uspto-grants-2015_12 |