HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Bromo-2-methylphenyl)-2,2,2-trifluoroethan-1-one → (1R)-1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Bromo-2-methylphenyl)-2,2,2-trifluoroethan-1-one | HCID 53402854 | — |
| Reactant | (R)-1-(4-Bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanol | HCID 117942080 | — |
| Catalyst | Iridium | HCID 23924 | — |
| Product | (1R)-1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethan-1-ol | HCID 117952721 | — |
Reaction Steps
Chiral reduction of 1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethanone using the Iridium complex-catalyzed hydrogenation as described for Intermediate 1, (R)-1-(4-bromo-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethanol provides (R)-1-(4-bromo-2-methylphenyl)-2,2,2-trifluoroethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199994B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-143b9adb11884ca385a9a3a6cc1c635d |
| Source note | uspto-grants-2015_12 |