4-Bromo-2-ethylbenzoic acid → HCID 117947778, compound

HRID 1499266Notes

Reaction equation

HRID 1499266 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:20][CH2:19][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:10][CH2:9]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:34]=[C:35]4[C:40](=[CH:41][CH:42]=3)[N:39]=[CH:38][C:37]([F:43])=[CH:36]4)=[CH:29][C:28]=2[CH3:44])[C:23]([F:26])([F:25])[F:24])[N:3]=1.Br[C:46]1C=CC(C(O)=O)=C(CC)C=1>>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][C:11]3([CH2:15][NH:14][C@H:13]([C:16]([OH:18])=[O:17])[CH2:12]3)[CH2:19][CH2:20]2)[CH:5]=[C:4]([O:21][C@H:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:34]=[C:35]4[C:40](=[CH:41][CH:42]=3)[N:39]=[CH:38][C:37]([F:43])=[CH:36]4)=[CH:29][C:28]=2[CH2:44][CH3:46])[C:23]([F:24])([F:26])[F:25])[N:3]=1

Participants

3

Reactant 2

HCID 106570054-Bromo-2-ethylbenzoic acidHCID 117952002HCID 117952002, compound

Product 1

HCID 117947778HCID 117947778, compound

Procedure

The title compound was prepared as described above for (S)-8-(2-amino-6-((R)-2,2,2-trifluoro-1-(4-(3-fluoroquinolin-6-yl)-2-methylphenyl)ethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid (Example 59c) starting with 4-bromo-2-ethylbenzoic acid in place of 4-bromo-2-methylbenzoic acid.

Sources & evidence

ORD record
ord-31473c22f4b142ddbe84d124a834b1c1
Source dataset
uspto-grants-2015_12
Patent number
US09199994B2

Reaction notes

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