HCID 53409023, compound → HCID 76070792, compound

Participants

Reaction Steps

The same procedure was employed as for amide 11, using 2-amino-2-methyl-1-(4-methylpiperazin-1-yl)propan-1-one hydrochloride, to provide the product 12 as the bisformate salt. 1H NMR (400 MHz, MeOH-d4) δ ppm 8.40 (s, 2 H), 7.11-7.21 (m, 3 H), 7.02-7.11 (m, 4 H), 4.39 (d, J=9.6 Hz, 1 H), 4.13 (d, J=9.1 Hz, 1 H), 3.96 (s, 2 H), 3.74 (br. s., 4 H), 3.34-3.52 (m, 3 H), 2.67 (t, J=4.6 Hz, 4 H), 2.60 (t, J=7.6 Hz, 2 H), 2.47 (s, 3 H), 2.19 (t, J=7.6 Hz, 2 H), 2.21 (s, 3 H), 2.14 (s, 3 H), 1.88 (quin, J=7.5 Hz, 2 H), 1.44 (s, 6 H). MS (ES+) [M+H]+=614.

Provenance & Evidence