HRID1499296

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11263760

TERT-BUTYL BUT-3-EN-1-YLCARBAMATE

C9H17NO2

结构：CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCCCN)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

HCID76070895

未命名化合物

PRODUCTS

生成物

结构：CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCCN)cc3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

HCID90177035

未命名化合物

PROCEDURE

实验过程

The same procedure was employed as used for the synthesis of (2S,3S,4R,5S,6R)-2-(3-(4-(5-aminopentyl)benzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate (16), using tert-butyl but-3-en-1-ylcarbamate as the reagent for the Heck reaction.

WORKUP

后处理

customfor the Heck reaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4f9c79df34964a51932212c24ffc1eb8
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09200025B2
来源说明: uspto-grants-2015_12

反应 SMILES

[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([S:19][CH3:20])[O:7][C@H:6]1[C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[C:23]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([CH2:35][CH2:36]CCCN)=[CH:31][CH:30]=2)[CH:22]=1)(=[O:3])[CH3:2].[CH2:41]([NH:45]C(=O)OC(C)(C)C)[CH2:42]C=C>>[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([S:19][CH3:20])[O:7][C@H:6]1[C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[C:23]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([CH2:35][CH2:36][CH2:42][CH2:41][NH2:45])=[CH:31][CH:30]=2)[CH:22]=1)(=[O:3])[CH3:2]