HRID1499299

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6503

Tromethamine

C4H11NO3

结构：CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCCNC(C)(C)CO)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

HCID90177781

未命名化合物

PRODUCTS

生成物

结构：CS[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(CCCCNC(CO)(CO)CO)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

HCID90183233

未命名化合物

PROCEDURE

实验过程

The same procedure was employed as for amine 24, using 2-amino-2-(hydroxyl-methyl)propane-1,3-diol, to provide the product 25 as the bisformate salt. 1H NMR (400 MHz, MeOH-d4) δ ppm 8.53 (s, 2 H), 6.98-7.23 (m, 7 H), 4.39 (d, J=9.3 Hz, 1 H), 4.13 (d, J=9.1 Hz, 1H), 3.94-4.03 (m, 2 H), 3.69 (s, 6 H), 3.34-3.50 (m, 3 H), 3.03-3.13 (m, 2 H), 2.58-2.69 (m, 2 H), 2.20 (s, 3 H), 2.12-2.18 (m, 3 H), 1.70 (m, 4 H). [M+H]+=537.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-518bc0160ddc4762958ae4e81593a26d
来源数据集: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09200025B2
来源说明: uspto-grants-2015_12

反应 SMILES

OCC(N[CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:35]=[CH:34][C:14]([CH2:15][C:16]2[CH:17]=[C:18]([C@H:23]3[C@H:28]([OH:29])[C@@H:27]([OH:30])[C@H:26]([OH:31])[C@@H:25]([S:32][CH3:33])[O:24]3)[CH:19]=[CH:20][C:21]=2[CH3:22])=[CH:13][CH:12]=1)(C)C.[NH2:36][C:37]([CH2:42][OH:43])([CH2:40][OH:41])[CH2:38][OH:39]>>[OH:39][CH2:38][C:37]([NH:36][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:15][C:16]2[CH:17]=[C:18]([C@H:23]3[C@H:28]([OH:29])[C@@H:27]([OH:30])[C@H:26]([OH:31])[C@@H:25]([S:32][CH3:33])[O:24]3)[CH:19]=[CH:20][C:21]=2[CH3:22])=[CH:34][CH:35]=1)([CH2:42][OH:43])[CH2:40][OH:41]