HCID 86596495, compound → HCID 86596494, compound

HRID 1499636Notes

Reaction equation

HRID 1499636 reaction equation
C[O:2][C:3]([CH2:5][CH2:6][O:7][CH2:8][C:9]([NH:26][C:27]([CH2:29][CH2:30][O:31][CH2:32][C:33]([NH:98][C:99]([CH2:101][CH2:102][CH2:103][NH:104][C:105](=[O:122])[O:106][CH2:107][C:108]1[C:109]2[C:114]([CH:115]=[C:116]3[C:121]=1[CH:120]=[CH:119][CH:118]=[CH:117]3)=[CH:113][CH:112]=[CH:111][CH:110]=2)=[O:100])([CH2:66][O:67][CH2:68][CH2:69][C:70]([NH:72][C:73]([CH2:90][O:91][CH2:92][CH2:93][C:94]([O:96]C)=[O:95])([CH2:82][O:83][CH2:84][CH2:85][C:86]([O:88]C)=[O:87])[CH2:74][O:75][CH2:76][CH2:77][C:78]([O:80]C)=[O:79])=[O:71])[CH2:34][O:35][CH2:36][CH2:37][C:38]([NH:40][C:41]([CH2:58][O:59][CH2:60][CH2:61][C:62]([O:64]C)=[O:63])([CH2:50][O:51][CH2:52][CH2:53][C:54]([O:56]C)=[O:55])[CH2:42][O:43][CH2:44][CH2:45][C:46]([O:48]C)=[O:47])=[O:39])=[O:28])([CH2:18][O:19][CH2:20][CH2:21][C:22]([O:24]C)=[O:23])[CH2:10][O:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15])=[O:4]>CC(C)=O.[OH-].[Na+]>[C:46]([CH2:45][CH2:44][O:43][CH2:42][C:41]([NH:40][C:38]([CH2:37][CH2:36][O:35][CH2:34][C:33]([NH:98][C:99]([CH2:101][CH2:102][CH2:103][NH:104][C:105](=[O:122])[O:106][CH2:107][C:108]1[C:109]2[C:114]([CH:115]=[C:116]3[C:121]=1[CH:120]=[CH:119][CH:118]=[CH:117]3)=[CH:113][CH:112]=[CH:111][CH:110]=2)=[O:100])([CH2:32][O:31][CH2:30][CH2:29][C:27]([NH:26][C:9]([CH2:10][O:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])([CH2:8][O:7][CH2:6][CH2:5][C:3]([OH:4])=[O:2])[CH2:18][O:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[O:28])[CH2:66][O:67][CH2:68][CH2:69][C:70]([NH:72][C:73]([CH2:82][O:83][CH2:84][CH2:85][C:86]([OH:88])=[O:87])([CH2:74][O:75][CH2:76][CH2:77][C:78]([OH:80])=[O:79])[CH2:90][O:91][CH2:92][CH2:93][C:94]([OH:96])=[O:95])=[O:71])=[O:39])([CH2:58][O:59][CH2:60][CH2:61][C:62]([OH:64])=[O:63])[CH2:50][O:51][CH2:52][CH2:53][C:54]([OH:56])=[O:55])([OH:48])=[O:47]

Participants

4

Reactant 1

HCID 86596495HCID 86596495, compound

Product 1

HCID 86596494HCID 86596494, compoundYield 68%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 14798Sodium HydroxideSolvent

Procedure

9-Anthrylmethyl N-[({tris[(2-{[(tris{[2-(methoxycarbonyl)ethoxy]methyl}methyl)amino]carbonyl} ethoxy)methyl]methyl}amino)carbonyl]propylcarbamate (0.60 g, 0.34 mmol) was dissolved in acetone (30 ml) and 0.20 N NaOH (30 ml). After stirring at room temperature for 1 d, the acetone was evaporated. The aqueous solution was washed with EA, stirred in an ice bath and acidified with dilute HCl. After the product was extracted with EA, the organic solution was dried with anhydrous MgSO4, filtered and evaporated. The total weight of the final yellow powder was 0.37 g and the yield was 68%.

Workup

  1. customthe acetone was evaporated
  2. washThe aqueous solution was washed with EA
  3. stirringstirred in an ice bath
  4. extractionAfter the product was extracted with EA
  5. dry with materialthe organic solution was dried with anhydrous MgSO4
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-8476320bc6484ed1b4fd4ad03b7b1917
Source dataset
uspto-grants-2015_12
Patent number
US09201067B2

Reaction notes

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