反应详情

To a solution of tert-butyl 3-(3-acetyl-5-chloro-6-fluoro-2-methoxyphenyl)azetidine-1-carboxylate (0.17 g, 0.48 mmol) in methanol (3 mL) cooled at 0° C. was added sodium tetrahydroborate (0.022 g, 0.57 mmol). The mixture was stirred at room temperature for 1 hour, then quenched with water, extracted with EtOAc. The organic layers were combined, dried over MgSO4 and concentrated to give the crude alcohol (0.19 g). LCMS calculated for C17H23ClFNO4Na (M+Na)+: m/z=382.1; Found: 382.0.

1. customquenched with water
2. extractionextracted with EtOAc
3. dry with materialdried over MgSO4
4. concentrationconcentrated