Acetone → HCID 71510102, compound

HRID 1499814Notes

Reaction equation

HRID 1499814 reaction equation
Cl.Cl.[NH:3]1[CH2:6][CH:5]([C:7]2[C:8]([O:30][CH2:31][CH3:32])=[C:9]([CH:15]([N:17]3[C:21]4=[N:22][CH:23]=[N:24][C:25]([NH2:26])=[C:20]4[C:19]([CH:27]([F:29])[F:28])=[N:18]3)[CH3:16])[CH:10]=[C:11]([Cl:14])[C:12]=2[F:13])[CH2:4]1.[CH3:33][C:34]([CH3:36])=O>>[Cl:14][C:11]1[C:12]([F:13])=[C:7]([CH:5]2[CH2:6][N:3]([CH:34]([CH3:36])[CH3:33])[CH2:4]2)[C:8]([O:30][CH2:31][CH3:32])=[C:9]([CH:15]([N:17]2[C:21]3=[N:22][CH:23]=[N:24][C:25]([NH2:26])=[C:20]3[C:19]([CH:27]([F:29])[F:28])=[N:18]2)[CH3:16])[CH:10]=1

Participants

3

Reactant 2

HCID 180AcetoneHCID 86677737HCID 86677737, compound

Product 1

HCID 71510102HCID 71510102, compound

Procedure

This compound was prepared using procedures analogous to those for Example 1 step 8, with 1-[1-(3-azetidin-3-yl-5-chloro-2-ethoxy-4-fluorophenyl)ethyl]-3-(difluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride and acetone as starting materials. The product was isolated as a racemic mixture. LCMS calculated for C22H27ClF3N6O (M+H)+: m/z=483.2; Found: 483.2

Workup

  1. customThis compound was prepared
  2. customThe product was isolated as a racemic mixture

Sources & evidence

ORD record
ord-64bba226e89b4448a6ca99c5a29142c5
Source dataset
uspto-grants-2015_12
Patent number
US09199982B2

Reaction notes

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