Acetyl chloride → 4'',5''-DICHLORO-2''-HYDROXYACETOPHENONE

Temperature

20 °C

A solution of 3,4-dichlorophenol [AK Scientific] (30 g, 18 mmol) in acetyl chloride (19 mL, 270 mmol) was stirred at 60° C. for 2 h. The reaction mixture was cooled to 20° C., treated with aluminum trichloride (37 g, 280 mmol) portionwise, and heated at 180° C. for 30 min. The reaction mixture was cooled to 20° C. and the solution hardened into a solid block that was not easy to break apart. This material was cooled to 0° C. and quenched slowly with 1 M HCl in portions. The solid block of material slowly broke apart with enough HCl and this heterogenous mixture was stirred at 20° C. overnight to ensure uniformity. The solid was filtered, washed with copious amounts of water, and dried under vacuum to give the desired product (38 g, quantitative) as a tan solid.

1. temperatureheated at 180° C. for 30 min
2. temperatureThe reaction mixture was cooled to 20° C.
3. temperatureThis material was cooled to 0° C.
4. customquenched slowly with 1 M HCl in portions
5. filtrationThe solid was filtered
6. washwashed with copious amounts of water
7. customdried under vacuum

ORD record

ord-fa04a469e5fd4d52ad12d07effbcce7c

Source dataset

uspto-grants-2015_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09199982B2