Sodium borohydride → 5-[3-chloro-2-cyano-5-(1-hydroxyethyl)-6-methoxyphenyl]N,N-dimethylpyridine-2-carboxamide

HRID 1499897Notes

Reaction equation

[BH4-].[Na+].[C:3]([C:6]1[C:7]([O:26][CH3:27])=[C:8]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([N:23]([CH3:25])[CH3:24])=[O:22])=[N:19][CH:20]=2)[C:9]([C:13]#[N:14])=[C:10]([Cl:12])[CH:11]=1)(=[O:5])[CH3:4]>CO>[Cl:12][C:10]1[C:9]([C:13]#[N:14])=[C:8]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([N:23]([CH3:25])[CH3:24])=[O:22])=[N:19][CH:20]=2)[C:7]([O:26][CH3:27])=[C:6]([CH:3]([OH:5])[CH3:4])[CH:11]=1

Participants

Conditions

Temperature: 0 °C

Procedure

Sodium tetrahydroborate (320 mg, 8.4 mmol) was added to a mixture of 5-(3-acetyl-5-chloro-6-cyano-2-methoxyphenyl)-N,N-dimethylpyridine-2-carboxamide (2 g, 6 mmol) in methanol (100 mL) cooled at 0° C. The reaction was stirred at 0° C. for 1 h, quenched with water and partitioned between water and EtOAc. The combined organic layer was washed with brine, dried over MgSO4, filtered and concentrated to give crude 5-[3-chloro-2-cyano-5-(1-hydroxyethyl)-6-methoxyphenyl]-N,N-dimethylpyridine-2-carboxamide as clear oil (2.0 g, 100%). LCMS calculated for C18H19ClN3O3 (M+H)+: m/z=360.1; found: 360.1.

Workup

customquenched with water
custompartitioned between water and EtOAc
washThe combined organic layer was washed with brine
dry with materialdried over MgSO4
filtrationfiltered
concentrationconcentrated

Sources & evidence

ORD record: ord-62271038140b4ea7aa3b3146658b14c6
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09199982B2

Reaction notes

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