Hydrochloric Acid → HCID 101575822, compound

Participants

Reaction Steps

10 (125 mg, 0.285 mmol) was suspended in a mixed solvent of 1,4-dioxane (50 ml), THF (50 ml), and MeOH (50 ml). The resultant mixture was charged with 2 N LiOH (28.5 ml, 57.0 mmol). The mixture was vigorously stirred for 15 hours at room temperature, then 2 N HCl (28.5 ml) was gradually added dropwise, and the mixture was adjusted to a pH of 2 to 3 by further adding 2 N HCl (2.0 ml) while checking the pH. The mixture was stirred for 20 minutes at room temperature, and then filtered using a membrane filter (H010A047A, Advantec). The filtered product was successively washed with water, methanol, and then chloroform, and dried under reduced pressure to obtain the target product Compound 1 (110 mg, 91%) as a glossy silvery-red film-like solid.

Provenance & Evidence