2,4-Dichloro-6-phenylpyrimidine → HCID 86702708, compound

HRID 1499981Notes

Reaction equation

HRID 1499981 reaction equation
[C:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1)#[N:2].[Cl:12][C:13]1[N:18]=[C:17](Cl)[CH:16]=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:14]=1>>[Cl:12][C:13]1[N:18]=[C:17]([C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:8]=2)[CH:16]=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:14]=1

Participants

3

Reactant 2

HCID 2415542,4-Dichloro-6-phenylpyrimidine3×HCID 27343253-Cyanophenylboronic acid

Product 1

HCID 86702708HCID 86702708, compound

Procedure

2-chloro-4-(3-cyanophenyl)-6-phenylpyrimidine was synthesized by the same method as in syntheses of 2,4-dichloro-6-phenylpyrimidine in the above (3-1-1), except that 2,4-dichloro-6-phenylpyrimidine was used in place of 2,4,6-trichloropyrimidine and that 3-cyanophenylboronic acid was used in place of phenylboronic acid.

Sources & evidence

ORD record
ord-bcf5154f07eb4e81ae140c8f114bfff3
Source dataset
uspto-grants-2015_12
Patent number
US09203043B2

Reaction notes

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