Sodium Iodide → HCID 86708938, compound

Participants

Reaction Steps

A suspension of 2-chloro-5-chloromethyl-pyridine (1.0 g, 6.17 mmol), 2-amino-pyridin-3-ol (0.68 g, 6.17 mmol) and NaI (0.93 g, 6.17 mmol) in acetone (10 mL) was refluxed for 12 h. After cooling to room temperature, solids were removed by filtration and the filtrate was evaporated under reduced pressure. The residue was triturated with ethyl acetate to yield 1.63 g of crude 2-amino-1-(6-chloro-pyridin-3-ylmethyl)-3-hydroxy-pyridinium chloride wich was used without further purification.

Provenance & Evidence