Arsenic Acid → HCID 131734265, compound

HRID 1500070Notes

Reaction equation

HRID 1500070 reaction equation
CC([O:4][C@@H:5]([CH2:10][N+:11]([CH3:14])([CH3:13])[CH3:12])[CH2:6][C:7]([O-:9])=[O:8])=O.[As:15](=[O:19])([OH:18])([OH:17])[OH:16].[CH2:20]([OH:22])[CH3:21]>>[As:15](=[O:16])([OH:19])([OH:18])[OH:17].[C:20]([C@@:5]([CH2:6][C:7](=[O:8])[O-:9])([CH2:10][N+:11]([CH3:12])([CH3:13])[CH3:14])[OH:4])(=[O:22])[CH3:21]

Participants

4

Reactant 3

HCID 234Arsenic AcidHCID 702Ethanol2×HCID 7045767Acetyl-L-carnitine2×

Product 1

HCID 131734265HCID 131734265, compoundYield 97.1%

Procedure

Acetyl L-carnitine (35.3 g) was weighted and put in a flask (250 ml), into which 80 ml ethanol was added. The mixture was heated to dissolve completely. An ethanol solution containing 31.0 g arsenic acid was slowly and dropwise added into the solution of acetyl L-carnitine, continued to stir for a further 1 h after the addition, cooled to room temperature, and white crystals were precipitated. After grinding, 64.4 g of white powder was obtained. Yield: 97.1%. Melting temperature: 150.6° C.-152.1° C. 1H-NMR (DMSO, 500 MHz), δ 2.28 (m, 2H), 3.16 (m, 9H), 3.35 (m, 2H), 4.36 (m, 1H), 9.51 (s, 3H); IR: 3423 cm−1, 2975 cm−1, 2399 cm−1, 1723 cm−1, 1477 cm−1, 1302 cm−1, 1191 cm−1, 1106 cm−1, 879 cm−1, 769 cm−1.

Workup

  1. customput in a flask
  2. temperatureThe mixture was heated
  3. dissolutionto dissolve completely
  4. additionafter the addition
  5. customwhite crystals were precipitated
  6. customAfter grinding

Sources & evidence

ORD record
ord-8d039b6441b24e3c9d724644b01a421f
Source dataset
uspto-grants-2015_12
Patent number
US09205071B2

Reaction notes

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