Sodium Hydroxide → HCID 15555159, compound

HRID 1500111Notes

Reaction equation

HRID 1500111 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[O:6][CH:7]=1.[OH-:15].[Na+]>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:6][CH:7]=[C:3]([CH2:2][OH:15])[N:4]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 71315274-(Chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole

Product 1

HCID 15555159HCID 15555159, compound

Procedure

6 g (26.307 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole were heated under reflux in 526 ml (52.613 mmol) of 0.1 N aqueous sodium hydroxide solution for 3 h. The mixture was then cooled to room temperature, and the precipitated solid was filtered off, washed with 0.1N aqueous sodium hydroxide solution and dried under high vacuum. This gave 4.79 g (85% of theory) of the target compound.

Workup

  1. filtrationthe precipitated solid was filtered off
  2. washwashed with 0.1N aqueous sodium hydroxide solution
  3. customdried under high vacuum

Sources & evidence

ORD record
ord-9ee06d367dc1491c85c320ec6a0af41c
Source dataset
uspto-grants-2015_12
Patent number
US09205077B2

Reaction notes

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