Potassium Carbonate → HCID 44548548, compound

Participants

Reaction Steps

494 mg (1.5 mmol) of 2-chloro-4-[4-(2-hydroxyethoxy)phenyl]-6-methoxypyridine-3,5-dicarbonitrile are initially charged in 5 ml of DMF, 140 mg (1.8 mmol) of sodium sulphide are added and the mixture is stirred at room temperature for 3 hours. 311 mg (2.25 mmol) of potassium carbonate and 307 mg (1.8 mmol) of 3-picolyl chloride hydrochloride are then added. The reaction mixture is stirred at 45° C. overnight and then purified by preparative HPLC (acetonitrile/water: 10:90→95:5, with 0.1% formic acid added). This gives 255 mg (40% of theory) of the target compound.

Provenance & Evidence