Triethylamine hydrochloride → P-Chloroacetophenone

Participants

Reaction Conditions

Reaction Steps

In 3-(4-chlorophenyl)-3-oxopropionic acid methyl ester (1.0 g, 0.0047 mol), N,N-dimethylacetamide (1 mL) and triethylamine hydrochloride (0.97 g, 0.0047×1.5 mol) were added and stirred at 140° C. for 3 hours under an argon atmosphere. In the reaction liquid, ethyl acetate and saturated sodium bicarbonate water were added, and the mixture was partitioned. After extracting the aqueous layer using ethyl acetate, the organic layer was dried using anhydrous sodium sulfate and concentrated. Thereafter, the dried and concentrated product was purified using a silica gel column, and a target product was obtained.

Provenance & Evidence