Sodium Hydroxide → HCID 74538749, compound

Participants

Reaction Steps

After adding toluene (1 mL) in 2-(4-chlorobenzyl)-8,8-dimethyl-1-oxo-7,9-dioxaspiro[4.5]decane-2-carboxylic acid methyl ester (10.0 g, 0.0273 mol), the mixture was suspended in a 0.5 M sodium hydroxide solution (27.3 mL, 0.0273 mol×0.5 mol) and reacted at 110° C. The reaction was continued by adding a 0.5 M sodium hydroxide solution (27.3 mL, 0.0273 mol×0.5 mol) every 2 hours (for three times total), and heating and stirring were performed for total of 9 hours. Following the completion of the reaction, the mixture was allowed to cool to room temperature and then subjected to extraction using toluene. The organic layer was washed with saturated brine solution, and then dried using anhydrous sodium sulfate. Thereafter, the dried product was purified using a silica gel column, and a target product was obtained.

Provenance & Evidence