HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propanal → (2S,3R)-3-(4-methoxyphenyl)-2-methyl-4-nitrobutanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propanal | HCID 527 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | trans-4-Methoxy-beta-nitrostyrene | HCID 697963 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (2S,3R)-3-(4-methoxyphenyl)-2-methyl-4-nitrobutanal | HCID 58500177 | — |
Reaction Steps
The title compound was prepared from propionaldehyde and (E)-1-methoxy-4-(2-nitrovinyl)benzene according to the general procedure. Both enantiomeric excess and diastereomeric ratio were determined by HPLC with an AS-H column at 230 nm (2-propanol:hexane=5:95), 1.0 mL/min; major enantiomer tmajor=42.10 min, minor enantiomer tminor=60.77 min. [α]D20=−4.6 (c=1.3, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206090B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-48895fa851dd4012ad2bb0540bef8ba0 |
| Source note | uspto-grants-2015_12 |