HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → (S)-3-(4-Methoxyphenyl)-2,2-dimethyl-4-nitrobutanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | trans-4-Methoxy-beta-nitrostyrene | HCID 697963 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-3-(4-Methoxyphenyl)-2,2-dimethyl-4-nitrobutanal | HCID 58500180 | — |
Reaction Steps
The title compound was prepared from trans-1-methoxy-4-(2-nitrovinyl) benzene and isobutyraldehyde according to general method. The enantiomeric excess was determined by HPLC with Chiralpak AS-H column at 210 nm (2-propanol:hexane=20:80), 1 ml/min; tmajor=12.7 min, tminor=15.8 min, [α]D20=+9.1 (c=1.2, CHCl3);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206090B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-84c25fab80e04e8c8e4269c611c26f1d |
| Source note | uspto-grants-2015_12 |