Acetic Acid → HCID 89816264, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 235.7 mg N-{5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2,3-dihydro-1H-inden-1-yl}propanamide (0.5 mmol) in 20 ml toluene was added 1304 mg manganese(IV)dioxide (15.0 mmol) and stirred at 20° C. for 12 h. After standing for about 2 d at room temperature 100 μl acetic acid were added and the mixture stirred for 15.5 h. The reaction mixture was filtered through celite-silica gel. The crude product (198 mg) was subjected to silica gel column chromatography yielding 20 mg of compound (I-A-2) and 67 mg pure N-{5-[3-(3,5-dichlorophenyl)-2-oxo-3-(trifluoromethyl)pyrrolidin-1-yl]-2,3-dihydro-1H-inden-1-yl}propanamide (I-B-2).

Provenance & Evidence