Thionyl Chloride → HCID 86663089, compound

HRID 1500237Notes

Reaction equation

HRID 1500237 reaction equation
[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([CH:8]([F:10])[F:9])[C:3]=1[C:11]([OH:13])=O.S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[C:4]([CH:8]([F:10])[F:9])[C:3]=1[C:11]([Cl:16])=[O:13]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 197546935-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 86663089HCID 86663089, compound

Procedure

3.2 g of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid and 44.3 mL of thionyl chloride were heated under reflux for 5 h. After cooling, the reaction mixture was concentrated under reduced pressure, giving 3.5 g of 5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride as a yellow oil.

Workup

  1. temperatureunder reflux for 5 h
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6a400ae587a34bafb102aefa2edc2f24
Source dataset
uspto-grants-2015_12
Patent number
US09206137B2

Reaction notes

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