HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ammonium Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate | HCID 10400532 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ammonium Chloride | HCID 25517 | — |
| Product | 2-(4-Methoxyphenyl)-1,3-thiazole-4-carboxylic acid | HCID 2763565 | — |
Reaction Steps
A mixture of 2-(4-Methoxy-phenyl)-thiazole-4-carboxylic acid ethyl ester and lithium hydroxide monohydrate (2.0 mmol, 84 mg) was diluted with a 2:1 mixture of THF:H2O (6 mL), and the resulting reaction was allowed to stir at room temperature for about 15 hours. The reaction mixture was then acidified using aqueous HCl (1 M, 10 mL), then dried via lyophilization to provide 2-(4-Methoxy-phenyl)-thiazole-4-carboxylic acid as an ammonium chloride salt. HPLC-MS RT. 1.37 minutes; mass calculated for formula C11H9NO3S 235.03, observed LCMS m/z 236.10 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206142B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-a80a65c57fbd4fab806dcd77c05c33f5 |
| Source note | uspto-grants-2015_12 |