HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 2745350, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 2-(5-methyl-1,2-oxazol-3-yl)-1,3-thiazole-4-carboxylate | HCID 2745347 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 2745350 | HCID 2745350 | 10% |
Reaction Steps
A mixture of 2-(5-methyl-isoxazol-3-yl)-thiazole-4-carboxylic acid ethyl ester (0.24 g, 1.0 mmol) and lithium hydroxide monohydrate (84 mg, 2.0 mmol) was dissolved in THF/H2O (2/1, 9 mL). The resulting reaction was allowed to stir at room temperature for about 15 hours, then acidified using 20% aqueous HCl. The solvent was removed by lyophilization to provide 2-(5-methyl-isoxazol-3-yl)-thiazole-4-carboxylic acid (21 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206142B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-08a762e299fc4b1e8d76396c8a95ea5f |
| Source note | uspto-grants-2015_12 |