HCID 86713171, compound → HCID 73603321, compound

Participants

Reaction Conditions

Reaction Steps

1-((4S,5R)-5-(4-(6-(difluoro(methylsulfonyl)methyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-2,2-dimethyloxazolidin-3-yl)-2,2-difluoroethanone (30 mg, 0.06 mmol) is suspended in 4N hydrochloric acid in dioxane, cooled to 5° C. then treated with 2 drops of water, stirred 30 minutes then purified by HPLC to give the title compound (13 mg). 1H NMR (400 MHz, DMSO-d6) δ: 3.40 (s, 3H), 4.25-4.50 (m, 3H), 4.92 (m, 1H), 6.20 (t, J=56 Hz, 1H), 7.52 (d, J=8.2, 1H), 7.82 (d, J=8.2 Hz, 1H), 7.93 (d, J=8.2, 1H), 8.38 (dd, J=8.2 Hz and 2.1 Hz, 1H), 8.83 (d, J=8.6 Hz, 1H), 9.13 (d, J=1.8 Hz, 1H). m/z (Cl) 453 [M+H].

Provenance & Evidence