Ammonia → HCID 86713178, compound

Participants

Reaction Steps

tert-Butyl-2-(5-bromopyridin-2-yl)-2,2-difluoroacetate (300 mg, 0.974 mmol) is dissolved in 7M ammonia in methanol (5 mL) and the mixture is stirred at ambient temperature for 3 days. The mixture is evaporated to dryness to give the title (240 mg). 1H-NMR (400 MHz, DMSO-d6) 7.70 (d, 1H), 8.05 (bs, 1H), 8.3 (d, 1H), 8.40 (bs, 1H), 8.85 (s, 1H). m/z (Cl) 251+253 (M+H).

Provenance & Evidence