Trifluoroacetic acid → HCID 73603622, compound

Participants

Reaction Steps

A solution of the product of step 3, Example 28 (554 mg, 1 mmol) in methylene chloride (20 ml) at 0° C. is treated with trifluoroacetic acid (10 ml) and allowed to warm to room temperature. After 30 minutes, water (3 drops) is added. The reaction mixture is stirred at room temperature for 3 hours. The reaction mixture is then diluted with toluene and evaporated. The material is purified by HPLC (Gemini NX C18MP A=0.1% trifluoroacetic acid in water MP B=0.1% trifluoroacetic acod in acetonitrile, Gradient 10% B to 50% in 10 min) to give title compound (248 mg): MS (ESI+) m/z 396.0 [M+H].

Provenance & Evidence