Hydrochloric Acid → N,N-Dimethyl-1-(2-(methylamino)ethyl)-4-phenylpiperidin-4-amine tris hydrochloride

Participants

Reaction Steps

HCl gas was passed through a solution of 9 g (1 eq) tert-butyl 2-(4-(dimethylamino)-4-phenylpiperidin-1-yl)ethyl(methyl)carbamate in 600 ml CH3Cl for 30 min. The reaction course was monitored by thin-layer chromatography (20% MeOH/CHCl3). Once the conversion was complete, the passage of HCl gas was continued for a further 30 min and the completeness of the conversion again monitored by thin-layer chromatography (20% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and 7.2 g (96%) of the desired product obtained in the form of a white solid.

Provenance & Evidence