Hydrochloric Acid → HCID 67367534, compound

Participants

Reaction Steps

HCl gas was passed through a solution of 10.5 g (1 eq) tert-butyl 2-(4-butyl-4-(dimethyl-amino)piperidin-1-yl)ethyl(methyl)carbamate in 1000 ml chloroform at 0° C. for ˜1 h. The reaction mixture was then stirred for 12 hours at room temperature. The reaction course was monitored by thin-layer chromatography (20% MeOH/CHCl3). Once the conversion was complete, the solvent was removed under reduced pressure and the residue washed with hexane (3×50 ml) and ethyl acetate (3×50 ml) and dried. 9 g (87%) of product were obtained in the form of a white solid.

Provenance & Evidence