Sodium borohydride → (4-(2-Fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methanol

Participants

Reaction Steps

To a stirred solution of 4-(2-Fluorophenyl)-1-methyl-1H-1,2,3-triazole-5-carbaldehyde 4 (38 g, 185.19 mmol) under nitrogen atmosphere in methanol (300 ml) was added sodium borohydride (8.407 g, 222.23 mmol) in portion wise at 0° C. and the reaction mass stirred for 20 min. The reaction was monitored by TLC and UPLC. The reaction mixture was quenched with water (500 ml) and concentrated to remove methanol and water. Then it was extracted with ethyl acetate (4×500 ml), combined organic layer was washed with brine (50 ml), dried over sodium sulphate, filtered and concentrated to afford crude mass (34 g, 88.6% mass balance). The above solid was triturated with hexane (3×100 ml), the supernant layer was decanted and the solid was dried to afford desired product (4-(2-Fluorophenyl)-1-methyl-1H-1,2,3-triazole-5-yl) methanol (31 g, 80.77%) as off-white solid.

Provenance & Evidence