HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Chloro-4-hydrazinylpyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Chloro-4-hydrazinylpyrimidine | HCID 16092198 | 94.8% |
Reaction Steps
A solution of 2,4-dichloropyrimidine (2.0 g) in EtOH (25 mL) was cooled to 0-20° C. and treated with hydrazine (2.8 mL). The progress of the reaction was followed by TLC using 10% MeOH:CH2Cl2 as mobile phase and visualizing under UV light. The mixture was concentrated under reduced pressure to afford 3.1 g of crude 2-chloro-4-hydrazinyl-pyrimidine (yield=94.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206158B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-309966fb13c842c1a31dab76d2ddba89 |
| Source note | uspto-grants-2015_12 |