反应详情

温度

27.5 °C

Sunitinib (10 g) was suspended in methanol (1540 mL) under stirring and L-malic acid (3.36 g) was added to it at a temperature 25-30° C. The reaction mass was stirred to get a clear solution. It was filtered and methanol was distilled off under vacuum below 40° C. Acetonitrile (50 mL) was charged and the solvent was distilled off. It was cooled to 25-30° C. 380 mL of acetonitrile was added to the mass and it was mentained at 45-50° C. under stirring for a period of 15 minutes. The reaction mass was cooled to 30-35° C. The solid obtained was filtered and washed with acetonitrile (10 mL). The resultant compound was suck dried and dried under vacuum over a period of 4-5 hrs at 50° C. to obtain sunitinib L-malate. (12.0 g; yield 90%)

1. stirringThe reaction mass was stirred
2. customto get a clear solution
3. filtrationIt was filtered
4. distillationmethanol was distilled off under vacuum below 40° C
5. additionAcetonitrile (50 mL) was charged
6. distillationthe solvent was distilled off
7. addition380 mL of acetonitrile was added to the mass and it
8. customwas mentained at 45-50° C.
9. stirringunder stirring for a period of 15 minutes
10. temperatureThe reaction mass was cooled to 30-35° C
11. customThe solid obtained
12. filtrationwas filtered
13. washwashed with acetonitrile (10 mL)
14. customdried
15. customdried under vacuum over a period of 4-5 hrs at 50° C.