反应详情

温度

30 °C

Sunitinib (1.0 g) was suspended in methanol (152 mL), followed by addition of sinapic acid (0.56 g) at 25-35° C. over a period of 15 minutes. After the stipulated time period, methanol was completely distilled off under vacuum below 45° C. The residue was treated with acetonitrile (38 mL) and refluxed. The reaction mass was maintained at reflux temperature for 60 minutes. The reaction mass was cooled to 25-35° C. for crystallization. The solid obtained was filtered, washed with acetonitrile, suck dried and dried under vacuum at 60° C. over 4-5 hr period to obtain sunitinib sinapinate.(1.3 g; yield:83%)

1. distillationAfter the stipulated time period, methanol was completely distilled off under vacuum below 45° C
2. additionThe residue was treated with acetonitrile (38 mL)
3. temperaturerefluxed
4. temperatureThe reaction mass was maintained
5. temperatureat reflux temperature for 60 minutes
6. customThe solid obtained
7. filtrationwas filtered
8. washwashed with acetonitrile, suck
9. customdried
10. customdried under vacuum at 60° C. over 4-5 hr period