Phosphoric Acid → HCID 131734274, compound

Participants

Reaction Conditions

Reaction Steps

Sunitinib (1.0 g) was suspended in methanol (152 mL), followed by addition of phosphoric acid (0.24 g) at 25-35° C. over a period of 15 minutes. After the stipulated time period, methanol was completely distilled off under vacuum below 45° C. The residue was treated with acetonitrile (38 mL) and refluxed. The reaction mass was maintained at reflux temperature for 60 minutes. The reaction mass was cooled to 25-35° C. for crystallization. The solid obtained was filtered, washed with acetonitrile, suck dried and dried under vacuum at 60° C. over 4-5 hr period to obtain sunitinib phosphate. (1.18 g; yield: 95%)

Provenance & Evidence