Potassium Carbonate → HCID 66707449, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial was added [1-(4-bromo-2-fluorobenzyl)-3,5-diethyl-1H-pyrazol-4-yl]acetic acid tert.-butyl ester (6.5 g), dioxane (30 ml), water (15 ml), molybdenum hexacarbonyl (2.1 g), Hermann's catalyst (1.5 g) and diisopropylethylamine (6 ml). After 20 min microwave heating at 150° C., the vial is allowed to cool to room temperature and the content is added to water. The reaction mixture is made alkaline with potassium carbonate and extracted twice with ethyl acetate. The aqueous phase is separated, acidified with glacial acetic acid and extracted several times with dichloromethane. The organic phase is then separated, dried over magnesium sulfate and concentrated in vacuo to yield 4-(4-tert.-butoxycarbonylmethyl-3,5-diethylpyrazol-1-ylmethyl)-3-fluorobenzoic acid (3.4 g; [M+H]=391; HPLC retention time 1.00 min (Method K)).

Provenance & Evidence