Acetic Acid → HCID 178503516, compound

HRID 1500455Notes

Reaction equation

HRID 1500455 reaction equation
[OH:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12.[OH-].[Na+].CI.[CH3:17]C(O)=O>O>[OH:1][C:2]1[N:7]=[C:6]([S:8][CH3:17])[N:5]=[C:4]2[NH:9][N:10]=[C:11]([CH3:12])[C:3]=12

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178434482HCID 178434482, compound

Product 1

HCID 178503516HCID 178503516, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 4-hydroxy-6-mercapto-3-methylpyrazolo[3,4-d]pyrimidine (A-1) (2.86 g, 11.8 mmol) and NaOH (0.8 g, 20 mmol) in water (20 mL) at 5° C., was added CH3I (2.0 g, 14.2 mmol). After stirred at ambient temperature for 30 min, the solution was acidified with HOAc to give the crude product of the title compound (A-2), which used in next step without further purification. MS-ESI (m/z): 197.0 (M+H)+.

Sources & evidence

ORD record
ord-bdbdf110cbb54d9797f0d4b8d7040e3b
Source dataset
uspto-grants-2015_12
Patent number
US09206166B2

Reaction notes

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