HCID 86718005, compound → HCID 86718006, compound

HRID 1500468Notes

Reaction equation

HRID 1500468 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[CH2:16][C@@H:17]([OH:19])[CH3:18])C1C=CC=CC=1>CO.[Pd]>[OH:19][C@@H:17]([CH3:18])[CH2:16][C:10]1[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 86718005HCID 86718005, compound

Product 1

HCID 86718006HCID 86718006, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture of (S)-1-(2-(benzyloxy)-5-methylphenyl)-propan-2-ol (3b) (0.50 g, 1.9 mmol) and Pd/C (100 mg, 20%) in MeOH (10 mL) was introduced H2 at ambient temperature. It was stirred at ambient temperature for 18 h. The mixture was filtered through Celite and concentrated to give the title compound (3c).

Workup

  1. additionwas introduced H2 at ambient temperature
  2. filtrationThe mixture was filtered through Celite
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f1724ca839ed424391628db0fff6d64e
Source dataset
uspto-grants-2015_12
Patent number
US09206166B2

Reaction notes

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