HCID 86718025, compound → HCID 86718026, compound

Participants

Reaction Steps

A mixture of (7-amino-5-methyl-4-(pyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)methanol (7f) (0.10 g, 0.39 mmol), PtO2 (50 mg, 50%) and TEA (0.061 mL, 0.78 mmol) in HOAc (5 mL) was introduced H2 and stirred at ambient temperature for 24 h (88 psi). The mixture was filtered, concentrated, and diluted with EtOAc (50 mL). A solution of ammonium hydroxide was added until pH=10, it was extracted with EtOAc (150 mL), washed with water, brine, dried and concentrated to give the title compound (7g) as a yellow oil. MS-ESI (m/z): 262 (M+1)+.

Provenance & Evidence