Diethyl Ether → HCID 178525515, compound

Participants

Reaction Steps

A solution of tert-butyl 4-({5-[(2,4-dichlorophenyl)methylcarbamoyl]-4-hydroxypyrimidin-2-yl}amino)-4-oxobutanoate (425 mg) in trifluoroacetic acid (3 mL) was left standing at room temperature for 30 minutes. Ether (60 mL) was added to the reaction solution, and the resulting suspension was filtered. The product collected by filtration was washed with ether, dried under reduced pressure, and then purified by reverse phase high performance liquid chromatography (acetonitrile/water, containing 0.1% formic acid) to obtain the title compound (144 mg).

Provenance & Evidence