Potassium Hydroxide → HCID 117778182, compound

Participants

Reaction Steps

Methyl 6-[(2,4-dimethoxyphenyl)methylamino]-4-methoxypyridine-3-carboxylate (1.16 g) was dissolved in a mixed solvent of tetrahydrofuran (10 mL) and methanol (10 mL). An aqueous potassium hydroxide solution (1 M, 7 mL) was added to the solution at room temperature. The reaction solution was stirred for 15 hours, and the organic solvent was then distilled off under reduced pressure. The obtained residue was diluted with water, and hydrochloric acid (1 M, 7.5 mL) was then added thereto. The resulting suspension was filtered, and the product collected by filtration was washed with water and dried under reduced pressure to obtain the title compound (0.890 g).

Provenance & Evidence