HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(4-Bromo-3-trifluoromethoxy-phenylcarbamoyl)-piperazin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester → 4-Piperidin-4-yl-piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxy-phenyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(4-Bromo-3-trifluoromethoxy-phenylcarbamoyl)-piperazin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86700511 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Piperidin-4-yl-piperazine-1-carboxylic acid (4-bromo-3-trifluoromethoxy-phenyl)-amide | HCID 86700519 | — |
Reaction Steps
A solution of 4-[4-(4-bromo-3-trifluoromethoxy-phenylcarbamoyl)-piperazin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (61.8 mg, 0.11 mmol) in 4 M of HCl in 1,4-dioxane (2.8 mL) was stirred at RT for 1 h to provide the title intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206159B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-64b623be125145f4b0fad151ddda0476 |
| Source note | uspto-grants-2015_12 |