HCID 178502446, compound → HCID 178502445, compound

Participants

Reaction Steps

A solution of 4-[4-(5-chloro-4′-{2-[(2S,4S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-4-methyl-pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-piperazin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 2TFA (12.94 mg, 0.012 mmol; Preparation 14) in 4 M HCl in 1,4-dioxane (0.21 mL) was stirred at RT for 30 min to provide the intermediate product {(S)-1-[(2S,4S)-2-(4-{5′-Chloro-4′-[(4-piperidin-4-yl-piperazine-1-carbonyl)-amino]-2′-trifluoromethoxy-biphenyl-4-yl}-1H-imidazol-2-yl)-4-methyl-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester.

Provenance & Evidence