2-Chloro-6-fluorobenzaldehyde → HCID 2797139, compound

HRID 1500536Notes

Reaction equation

HRID 1500536 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=O.[S:11]1[CH2:17][C:15](=[O:16])[NH:14][C:12]1=[S:13].C([O-])(=O)C.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=[C:17]1[S:11][C:12](=[S:13])[NH:14][C:15]1=[O:16]

Participants

5

Reactant 3

HCID 678472-Chloro-6-fluorobenzaldehydeHCID 517045Sodium AcetateHCID 1201546Rhodanine

Product 1

HCID 2797139HCID 2797139, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Chloro-6-fluorobenzaldehyde (9.50 g), rhodanine (7.98 g), and acetic acid (57 ml) were stirred at room temperature. Anhydrous sodium acetate (14.0 g) was added to the obtained suspension, and the mixture was heated with stirring for 2 hours. The reaction mixture was allowed to cool to room temperature, and ice water (190 ml) was added thereto. The precipitated crystals were collected by filtration, washed with water, and then dried to obtain 2-chloro-6-fluorobenzylidenerhodanine.

Workup

  1. temperaturethe mixture was heated
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-003488f145534353be4d195277396dcf
Source dataset
uspto-grants-2015_12
Patent number
US09206169B2

Reaction notes

Loading…