7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one → 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one hydrochloride

HRID 1500560Notes

Reaction equation

HRID 1500560 reaction equation
C(O)C.[ClH:4].[S:5]1[CH:9]=[CH:8][C:7]2[C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:34]=[C:33]5[C:28]([CH2:29][CH2:30][C:31](=[O:35])[NH:32]5)=[CH:27][CH:26]=4)[CH2:16][CH2:15]3)=[CH:11][CH:12]=[CH:13][C:6]1=2>C(O)C>[ClH:4].[S:5]1[CH:9]=[CH:8][C:7]2[C:10]([N:14]3[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][CH2:22][CH2:23][O:24][C:25]4[CH:34]=[C:33]5[C:28]([CH2:29][CH2:30][C:31](=[O:35])[NH:32]5)=[CH:27][CH:26]=4)[CH2:18][CH2:19]3)=[CH:11][CH:12]=[CH:13][C:6]1=2

Participants

4

Reactant 2

HCID 118572457-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3,4-dihydro-1H-quinolin-2-oneHCID 21887872Ethanol hydrochloride

Product 1

HCID 668847207-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1N hydrochloric acid ethanol solution was added to an ethanol solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one prepared in Example 11, and precipitated crystals were filtrated and recrystallized from 90% aqueous ethanol and 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one hydrochloride was obtained as slightly brown needle-like crystals.

Workup

  1. customprecipitated crystals
  2. filtrationwere filtrated
  3. customrecrystallized from 90% aqueous ethanol

Sources & evidence

ORD record
ord-d1a05ff6b6314352a8f84c7b1d55459a
Source dataset
uspto-grants-2015_12
Patent number
US09206167B2

Reaction notes

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