HCID 10421686, compound → HCID 66885600, compound

HRID 1500566Notes

Reaction equation

HRID 1500566 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]4[CH2:29][CH2:28][C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[C:21]4=[O:30])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:31]CCCCN1CCC2C(=CC=CC=2)C1=O.C(O)C.Cl>C(O)C>[ClH:31].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]4[CH2:29][CH2:28][C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[C:21]4=[O:30])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 10421686HCID 10421686, compoundHCID 21887872Ethanol hydrochlorideHCID 66885601HCID 66885601, compound

Product 1

HCID 66885600HCID 66885600, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By a similar method as in Example 1, 2-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl]-3,4-dihydro-2H-isoquinolin-1-one was prepared from 2-(4-chlorobutyl)-3,4-dihydro-2H-isoquinolin-1-one, and after it was made into an ethanol solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from a mixed solvent of isopropyl alcohol-ethanol and thereby 2-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl]-3,4-dihydro-2H-isoquinolin-1-one hydrochloride was obtained.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from a mixed solvent of isopropyl alcohol-ethanol

Sources & evidence

ORD record
ord-b754c8dbd5284ca2a3f486a3885c7ec9
Source dataset
uspto-grants-2015_12
Patent number
US09206167B2

Reaction notes

Loading…