Fumaric Acid → HCID 66885603, compound

HRID 1500583Notes

Reaction equation

HRID 1500583 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][O:27][C:28]4[CH:37]=[C:36]5[C:31]([CH2:32][CH2:33][N:34]([CH3:39])[C:35]5=[O:38])=[CH:30][CH:29]=4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=[CH:17][C:10]1=2>C(O)C>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][O:27][C:28]4[CH:37]=[C:36]5[C:31]([CH2:32][CH2:33][N:34]([CH3:39])[C:35]5=[O:38])=[CH:30][CH:29]=4)[CH2:22][CH2:23]3)=[CH:15][CH:16]=[CH:17][C:10]1=2

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 11978936HCID 11978936, compound

Product 1

HCID 66885603HCID 66885603, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Fumaric acid was added to an ethanol solution of 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one and the solvent was evaporated under reduced pressure. The residue was recrystallized from 70% ethanol and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one fumarate was obtained in the form of a pale yellow powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from 70% ethanol

Sources & evidence

ORD record
ord-d8b212a151204061a8b100941061a8ad
Source dataset
uspto-grants-2015_12
Patent number
US09206167B2

Reaction notes

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