Maleic Acid → HCID 66884752, compound

HRID 1500585Notes

Reaction equation

HRID 1500585 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][O:27][C:28]4[CH:37]=[C:36]5[C:31]([CH2:32][CH2:33][N:34]([CH3:39])[C:35]5=[O:38])=[CH:30][CH:29]=4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=[CH:17][C:10]1=2>CO.ClCCl>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][O:27][C:28]4[CH:37]=[C:36]5[C:31]([CH2:32][CH2:33][N:34]([CH3:39])[C:35]5=[O:38])=[CH:30][CH:29]=4)[CH2:22][CH2:23]3)=[CH:15][CH:16]=[CH:17][C:10]1=2

Participants

5

Reactant 2

HCID 444266Maleic AcidHCID 11978936HCID 11978936, compound

Product 1

HCID 66884752HCID 66884752, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 6344DichloromethaneSolvent

Procedure

A methanol solution of maleic acid was added to a solution of 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from ethanol and ethyl acetate and thereby 7-[3-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)propoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one maleate was obtained in the form of a white powder.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was recrystallized from ethanol and ethyl acetate

Sources & evidence

ORD record
ord-4bf06c74a7524c0a8ef09e16f54aef1e
Source dataset
uspto-grants-2015_12
Patent number
US09206167B2

Reaction notes

Loading…