HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(3-Hydroxymethyl-phenyl)-acrylic acid methyl ester → Methyl 3-[3-(hydroxymethyl)phenyl]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(3-Hydroxymethyl-phenyl)-acrylic acid methyl ester | HCID 59794688 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 3-[3-(hydroxymethyl)phenyl]propanoate | HCID 59794668 | 83.2% |
Reaction Steps
(Ph3P)3RhCl (11.5 mg, 0.012 mmol) was added to a solution of 17 (25 mg, 0.13 mmol) in 0.400 mL ethanol. The reaction was stirred under 1 atm H2 balloon for 20 h and then was filtered through Celite. Evaporation to dryness and purification by flash chromatography on silica gel (30% ethyl acetate/hexanes) gave compound 18 (21 mg, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732443B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e6ff693431444151971f276948e1e778 |
| Source note | uspto-grants-2010_06 |