反应详情

A 2.5 N aqueous solution of sodium hydroxide (36 mL) was added to a solution of ethyl pyrazolo[1,5-a]pyridine-3-carboxylate (Preparation 22a, 4.3 g, 22.6 mmol) in ethanol (70 mL) and the resulting reaction mixture was heated to reflux for 1 h. After evaporation of the ethanol, the reaction mixture was acidified with 15% aqueous hydrochloric acid solution. The solid formed was filtered, washed with water and diethyl ether and dried to give the title compound (2.81 g, 77%) as a pale pink solid.

1. customthe resulting reaction mixture
2. temperaturewas heated
3. temperatureto reflux for 1 h
4. customAfter evaporation of the ethanol
5. customThe solid formed
6. filtrationwas filtered
7. washwashed with water and diethyl ether
8. customdried